Wnt-Induced Deubiquitination FoxM1 Abrogates the Inhibition of ICAT to β-catenin transactivation
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منابع مشابه
Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.
A key step of Wnt signaling activation is the recruitment of β-catenin to the Wnt target-gene promoter in the nucleus, but its mechanisms are largely unknown. Here, we identified FoxM1 as a novel target of Wnt signaling, which is essential for β-catenin/TCF4 transactivation. GSK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7. Wnt signaling activation in...
متن کاملWnt-induced deubiquitination FoxM1 ensures nucleus b-catenin transactivation
A key step of Wnt signaling activation is the recruitment of b-catenin to the Wnt target-gene promoter in the nucleus, but its mechanisms are largely unknown. Here, we identified FoxM1 as a novel target of Wnt signaling, which is essential for b-catenin/TCF4 transactivation. GSK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7. Wnt signaling activation in...
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